2. Metabolic Disease

Metabolic Disease

Metabolic Disease

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Metabolic diseases is defined by a constellation of interconnected physiological, biochemical, clinical, and metabolic factors that directly increases the risk of cardiovascular disease, type 2 diabetes mellitus, and all cause mortality. Associated conditions include hyperuricemia, fatty liver (especially in concurrent obesity) progressing to nonalcoholic fatty liver disease, polycystic ovarian syndrome (in women), erectile dysfunction (in men), and acanthosis nigricans. Metabolic disease modeling is an essential component of biomedical research and a mandatory prerequisite for the treatment of human disease. Somatic genome editing using CRISPR/Cas9 might be used to establish novel metabolic disease models.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-W725504
    2-Hydroxy-3-methylbutanoic acid-d7 98%
    2-Hydroxy-3-methylbutanoic acid-d7 is the deuterium labeled 2-Hydroxy-3-methylbutanoic acid (HY-W008150). 2-Hydroxy-3-methylbutanoic acid is an α-hydroxy analogue of valine and a valine precursor that reduces urea excretion. 2-Hydroxy-3-methylbutanoic acid can promote the growth of chickens and rats, and is converted into valine in the body, participating in protein synthesis and maintaining nitrogen balance, thereby supporting animal growth and development. 2-Hydroxy-3-methylbutanoic acid has a more significant effect on the valine-deficient dietary model. 2-Hydroxy-3-methylbutanoic acid is mainly used in animal nutrition research to evaluate its potential application as a nitrogen source substitute in feed.
    2-Hydroxy-3-methylbutanoic acid-d7
  • HY-W725644
    L-2-Aminoadipate adenylate 1148038-11-2 98%
    L-2-Aminoadipate adenylate is a nucleoside metabolite.
    L-2-Aminoadipate adenylate
  • HY-W725836
    13:0 Lyso PI 1246430-02-3 98%
    13:0 Lyso PI is a lipid that can be used to prepare lipid nanoparticles (LNPs) for drug delivery.
    13:0 Lyso PI
  • HY-W726084
    1,2:5,6-Di-O-isopropylidene-L-chiro-inositol 65556-81-2 98%
    1,2:5,6-Di-O-isopropylidene-L-chiro-inositol is a derivative of inositol.
    1,2:5,6-Di-O-isopropylidene-L-chiro-inositol
  • HY-W727627
    5-O-Coumaroylquinic acid 87099-71-6 98%
    5-O-Coumaroylquinic acid is a potent, reversible, non-competitive α-amylase inhibitor with an IC50 value of 69.39 μM. 5-O-Coumaroylquinic acid can be used in diabetes research.
    5-O-Coumaroylquinic acid
  • HY-W727728
    MK-8666 1544739-75-4 98%
    MK-8666 is a potent and selective partial GPR40 agonist (EC50 = 0.54 nM for human GPR40). MK-8666 shows selectivity over GPR119, GPR43, GPR41, GPR120, and other G-protein-coupled receptors (GPCRs). MK-8666 reduces glucose in the rodent. MK-8666 can be used for type 2 diabetes research[1][2].
    MK-8666
  • HY-W727757
    Pristanic acid-d6 (>90%) 98%
    Pristanic acid-d6 (>90%) is the deuterium labeled Pristanic acid (HY-113024). Pristanic acid is an endogenous metabolite present in Blood that can be used for the research of Alpha Methylacyl CoA Racemase Deficiency and Zellweger Syndrome.
    Pristanic acid-d6 (>90%)
  • HY-W728448
    7,8-Dihydroxykynurenate 2547-48-0 98%
    7,8-Dihydroxykynurenate is a product of the tryptophan metabolic pathway.
    7,8-Dihydroxykynurenate
  • HY-W740010
    N-Desmethyl rosuvastatin disodium hydrate 99.1%
    N-Desmethyl rosuvastatin disodium hydrate is an active metabolite of HMG-CoA reductase (HMGCR) inhibitor rosuvastatin (HY-17504). N-Desmethyl rosuvastatin disodium hydrate can be utilized in research of rosuvastatin metabolism.
    N-Desmethyl rosuvastatin disodium hydrate
  • HY-W740244
    4’-Hydroxy Trazodone 53818-10-3 98%
    4’-hydroxy Trazodone is a metabolite of the antidepressant and sedative trazodone. It is an inhibitor of organic anion transporter 3 (OAT3; Ki=16.9 μM) and is selective for OAT3 over OAT1 (Ki=>200 μM).
    4’-Hydroxy Trazodone
  • HY-W740341
    3-Pyridinemethanol-d6 1189493-62-6 98%
    3-Pyridinemethanol-d6 is the deuterium labeled 3-Pyridinemethanol (HY-B0893). 3-Pyridinemethanol (Nicotinyl alcohol), a pyridine derivative, is a cholesterol-lowering agent.
    3-Pyridinemethanol-d6
  • HY-W740434
    1-Palmitoyl-2-linoleoyl-rac-glycerol 73649-99-7 98%
    1-Palmitoyl-2-linoleoyl-rac-glycerol is a diacylglycerol that contains Palmitic acid (HY-N0830).
    1-Palmitoyl-2-linoleoyl-rac-glycerol
  • HY-W740498
    Raspberry ketone-d5 182219-43-8 98%
    Raspberry ketone-d5 (Frambione-d5; 4-(4-Hydroxyphenyl)-2-butanone-d5) is the deuterium labeled Raspberry ketone (HY-N1426). Raspberry ketone is a major aromatic compound of red raspberry, widely used as a fragrance in cosmetics and as a flavoring agent in foodstuff; also shows PPAR-α agonistic activity.
    Raspberry ketone-d5
  • HY-W740965
    Linolenic acid glycidyl ester-d5 1287393-54-7 98%
    Linolenic acid glycidyl ester-d5 (9,12,15-Octadecatrienoic acid-d5; Glycidyl linolenate-d5) is the deuterium labeled Linolenic acid glycidyl ester (HY-W587910). Linolenic acid glycidyl ester (9,12,15-Octadecatrienoic acid; Glycidyl linolenate) is an ester product.
    Linolenic acid glycidyl ester-d5
  • HY-W741284
    Glycidyl myristate-d5 1330180-72-7 98%
    Glycidyl myristate-d5 (Myristic acid glycidyl ester-d5; Glycidyl tetradecanoate-d5) is the deuterium labeled Glycidyl myristate (HY-W702174). Glycidyl myristate (Myristic acid glycidyl ester; Glycidyl tetradecanoate) is an ester product.
    Glycidyl myristate-d5
  • HY-W741628
    7-Aminonimetazepam-d3 1346603-85-7 98%
    7-Aminonimetazepam-d3 is the deuterium labeled 7-Aminonimetazepam (HY-W088846). 7-Aminonimetazepam is the metabolite of Nimetazepam, which is found in the urine.
    7-Aminonimetazepam-d3
  • HY-W742312
    Brallobarbitone 561-86-4 98%
    Brallobarbitone is a positive allosteric modulator of GABAA receptor. Brallobarbitone can be used in the research of β-cell dysfunction.
    Brallobarbitone
  • HY-W742940
    O-Arachidonoyl glycidol-d5 2519458-54-7 98%
    O-Arachidonoyl glycidol-d5 is the deuterium labeled O-Arachidonoyl glycidol (HY-131995). O-Arachidonoyl glycidol (compound 1) is a 2-arachidonoylglycerol (2-AG) analog. O-Arachidonoyl glycidol inhibits cytosolic 2-oleoylglycerol (2-OG) hydrolysis with an IC50 value of 4.5 μM. O-Arachidonoyl glycidol blocks 2-OG hydrolysis in membrane fractions and anandamide hydrolysis with IC50s of 19, 12 μM, respectively.
    O-Arachidonoyl glycidol-d5
  • HY-W743526
    2-Chloropropane-1,3-diyl dioleate-d5 98%
    2-Chloropropane-1,3-diyl dioleate-d5 (1,1′-(2-Chloro-1,3-propanediyl) di-(9Z)-9-octadecenoate-d5) is the deuterium labeled 2-Chloropropane-1,3-diyl dioleate (HY-W705777). 2-Chloropropane-1,3-diyl dioleate (1,1′-(2-Chloro-1,3-propanediyl) di-(9Z)-9-octadecenoate) is an ester product.
    2-Chloropropane-1,3-diyl dioleate-d5
  • HY-W743727
    Cytisine-d4 2714473-76-2 98%
    Cytisine-d4 is the deuterium labeled Cytisinicline (HY-N0175). Cytisinicline (Cytisine) is an alkaloid. Cytisinicline (Cytisine) is a partial agonist of α4β2 nAChRs, and partial to full agonist at β4 containing receptors and α7 receptors. Has been used medically to help with smoking cessation.
    Cytisine-d4
Cat. No. Product Name / Synonyms Application Reactivity